No, interbreeding isn't common in Star Trek, though all of the 'half'-breeds featured quite prominently.
Proving why Sela is blond, will take up a lot of graphic space, something i am not yet up to par with. It maybe because her mother was blond? Science has proven over time that there will have to be a dominant gene for every characteristic, i.e boys will in most cases inherit their coloring from their father, and girls from their mother. With the human genes diluted over the ages, it would stand to reason that other recognizable features like ridges, ears, etc., be prevalent. The same can apply vice versa.
Proven also, is that the same 60 genes that is needed when a new organism is formed, can combine to infinity, resulting in different organisms with the same genes. Time, conditions and environment playing a major role in the finished product.
It is also interesting to note that the same 60 genes, and the protein therein, can be found in EVERY living organism on earth, and maybe in the universe, from a blade of grass right up to humans.